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Excessive bone resorption in human plasmacytomas: direct induction by tumour cells in vivo
Author(s) -
BATAILLE REGIS,
CHAPPARD DANIEL,
BASLE MICHEL
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05609.x
Subject(s) - resorption , biopsy , in vivo , medicine , bone resorption , pathology , plasmacytoma , cancer research , multiple myeloma , biology , microbiology and biotechnology
Summary. We studied the bone resorption (BR) in 82 patients with overt plasmacytomas (PCT) by histomorpho‐metry. All the solitary PCT and 90% of overt PCT in complete remission lacked excessive BR. In contrast, 73% of the 68 patients with active overt PCT had an excessive BR. This excessive BR was highly related to the presence of tumour cells within the bone sample. Indeed, 92% of patients with active PCT and tumour cells within the biopsy had an excessive BR. On the other hand, 70% of patients with active PCT but lacking tumour cells within the biopsy had normal BR.