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Expression of lymphoid‐associated antigens in mast cells: report of a case of systemic mast cell disease
Author(s) -
Escribano Luis,
Orfao Alberto,
Villarrubia Jesús,
Cerveró Carlos,
Velasco José L.,
Martín Flor,
Miguel Jesus F. San,
Navarro Jose L.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05417.x
Subject(s) - cd22 , cd20 , cd19 , bone marrow , cd5 , antigen , mast cell , immunology , cd8 , cd3 , lymphatic system , immunofluorescence , pathology , immunophenotyping , biology , medicine , antibody
Summary. In this study the expression of‘classically’considered lymphoid‐associated antigens (CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD19, CD20, and CD22) was explored both in peripheral blood (PB) and bone marrow (BM) mast cells (MC) in a case of systemic mast cell disease (SMCD) by means of using multiple stainings and a direct immunofluorescence technique. CD2 and CD22 were expressed in both PB and BM MC, all the remaining lymphoid‐associated markers were negative. Our results suggest that the reactivity for both CD2 and CD22 in PB and BM MC would be aberrant.