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EBV‐associated lymphoproliferative syndrome with a distinct 69 base‐pair deletion in the LMP‐1 oncogene
Author(s) -
Klein Christoph,
Rothenberger Sylvia,
Niemeyer Charlotte,
Bachmann Edith,
Odermatt Bernhard,
Bohm Norbert,
Brandis Matthias,
Knecht Hans
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05416.x
Subject(s) - biology , lymph node , immunoglobulin heavy chain , point mutation , immunology , lymph , antibody , gene , base pair , pathology , mutation , virology , medicine , genetics
Summary. We describe an immunocompetent 12‐year‐old boy with chronic EBV infection and lymphoid interstitial pneumonitis. Lymph node biopsies showed effacement of the architecture with polymorphic cellular infiltrates, consisting predominantly of T cells and natural killer cells. No clonal rearrangement of TCR or immunoglobulin genes was seen. DNA was extracted from hilar lymph nodes; sequencing of the carboxy terminal region of the latent membrane protein 1 (LMP‐1) oncogene revealed a 69 base‐pair deletion and four point mutations. Immunosuppressive treatment with prednisone and cyclosporine reversed the lymphadenopathy.