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BCR‐ABL rearrangement and Variant’Philadelphia chromosome in de novo acute myelogenous leukaemia FAB subtype M1
Author(s) -
Cigudosa Juan C.,
Almeida M. Teresa Acosta,
Carrasco Vicente,
Bello Teófilo,
Carrasco José Luis,
Gomez Ana Otero,
Talavera Juan Garcia,
Garcia Miranda José Luis
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05414.x
Subject(s) - chromosomal translocation , breakpoint cluster region , philadelphia chromosome , biology , abl , chronic myelogenous leukemia , cytogenetics , gene rearrangement , chromosome 22 , chromosome , exon , genetics , cancer research , microbiology and biotechnology , leukemia , gene , receptor , tyrosine kinase
Summary. We report a case of de novo acute myelogenous leukaemia FAB subtype Ml that presents a cytogenetic complex translocation between chromosomes 7, 9 and 22, producing a ‘variant’ Philadelphia chromosome. Molecular analysis revealed a BCR‐ABL rearrangement involving exons b3 and a2 (b3a2). Haematological parameters and genetic analysis again raise the problem of the true nature of this disease, which is briefly discussed.