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Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues
Author(s) -
Dürkop Horst,
Latza Ute,
Himmelreich Petra,
Stein Harald
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05413.x
Subject(s) - antigen , lymphoma , immunostaining , malignant histiocytosis , biology , t cell , cell culture , pathology , monoclonal antibody , immunohistochemistry , antibody , cancer research , immunology , microbiology and biotechnology , medicine , histiocyte , immune system , genetics
Summary. The Ber‐ACT35 mAb was raised against the human T‐cell lymphotrophic virus (HTLV) 1‐transformed, CD4 + HUT 102 cell line and recognizes the human homologue of the 0X40 (hOX40) antigen. The analysis of the expression of hOX40 by immunohistochernical techniques in malignant lymphomas, carcinomas and non‐malignant tissues of different organs shows that hOX40 expression was almost completely restricted to T lymphocytes. Besides T cells only a small subpopulation of macrophages in Langerhans’cell histiocytosis and a few blasts in B‐cell non‐Hodgkin's lymphoma (B‐NHL) revealed a faint immunostaining with the Ber‐ACT35 mAb. Furthermore, most of the hOX40 + T‐cells are CD4 + .