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Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain
Author(s) -
Pastore Cristina,
Gloghini Annunziata,
Volpe Gisella,
Nomdedeu Josep,
Leonardo Eugenio,
Mazza Umberto,
Saglio Giuseppe,
Carbonb Antonino,
Gaidano Gianluca
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05410.x
Subject(s) - sarcoma , medicine , virology , distribution (mathematics) , hematologic neoplasms , pathology , cancer , mathematics , mathematical analysis
Summary. In this study we have tested the distribution of Kaposi's sarcoma herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid neoplasia in Italy and Spain. 180 cases of lymphoid malignancies representative of the major histologic and immunophenotypic categories of B‐ and T‐cell tumours were analysed by means of a polymerase chain reaction‐based assay. KSHV sequences were consistently absent in all categories of lymphoid malignancies studied, with the exception of a subset of B‐cell non‐Hodgkin's lymphomas localizing in the pleural, pericardial or peritoneal cavities, and fulfilling the diagnostic criteria of body‐cavity‐based lymphoma. The selective and consistent association of KSHV sequences with cases of body‐cavity‐based lymphoma throughout the spectrum of lymphoid neoplasms suggests that KSHV may be involved in the pathogenesis of this peculiar type of lymphoid malignancy.