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Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters
Author(s) -
Hakim I.,
Amariglio N.,
BrokSimoni F.,
Berkowitz M.,
Rosner E.,
Kneller A.,
Hulu N.,
Ramot B.,
BenBassat I.,
Silverman G. J.,
Rechavi G.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05409.x
Subject(s) - antibody , biology , immunology , human leukocyte antigen , phenotype , cd5 , gene , genetics , immunoglobulin e , antigen
Summary. We report three family members, including a set of identical twins, who developed CD5 positive B‐CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related V H regions belonging to the V H 3 subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.