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Severe arterial thrombosis in a congenitally factor VII deficient patient
Author(s) -
Escoffre M.,
Zini J. M.,
Schuamser L.,
Mazoyer E.,
Soria C.,
Tobelem G.,
Dupuy E.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05378.x
Subject(s) - medicine , thrombosis , thrombus , factor vii , surgery , clotting factor , platelet , heparin , cardiology , gastroenterology , coagulation
Summary. We report a patient with congenital factor VII deficiency who developed severe arterial thrombosis. A 63‐year‐old‐woman presented low factor VII clotting activity, amidolytic activity and antigen level < 4%. Activated factor VII plasmatic level was < 0.03 ng/ml compared to 4 ng/ml for the control value. She developed severe aorto‐iliac thrombosis. 7d before the thrombotic event, factor VII replacement therapy had been infused. Successful low molecular weight heparin therapy led to total disappearance of the aortoiliac thrombus without bleeding complications. This suggests that factor VII infusion might have a thrombogenic effect in vivo and might be responsible for thrombosis.