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Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study
Author(s) -
SeckerWalker L. M.,
Mehta A.,
Bain B.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05329.x
Subject(s) - gastroenterology , malignancy , medicine , myeloid , thrombocytosis , monosomy , pathology , biology , karyotype , platelet , chromosome , genetics , gene
Summary. Cytogenetic and clinical details are presented for 66 patients with myeloid malignancy and chromosome abnormalities of 3q21 and/or 3q26 (3qabns). Bone marrow and/or peripheral blood morphology was assessed for 52 cases. 3qabns in Philadelphia negative (Ph–ve) and positive (Ph + ve) cases were inv(3)(q21q26), (21 Ph‐ve, 6Ph + ve); t(3;3)(q21;q26) (nine Ph‐ve, four Ph + ve); and t(3;21)(q26;q22) (four Ph‐ve, six Ph + ve). Ph‐ve cases also had t(l;3)(p36;q21) (three cases), and t(3;5)(q21;q31)/ (q21;q35)/(q26;q21) (five cases aged <40 years). Three cases, aged < 30 years, had t(3;12)(q26;p13) which defines a new 3qabn subgroup. Monosomy 7 and/or 5q‐ accompanied inv(3) or t(3;3) in 17/30 cases. All cases had a myeloid malignancy (predominantly AML M1, M4 or M7), frequent trilineage myelodysplasia, and markedly abnormal megakaryopoiesis with micromegakaryocytes (<30/mi). Thrombocytosis occurred in two cases only. Most Ph + ve cases were in myeloid blast crisis and in Ph + ve cases alone, micro‐megakaryocytes were uniquely small (10 μm) in 7/11 cases. There were equal numbers of males and females. Seven secondary leukaemias were found in Ph–ve cases with inv(3), t(3;3), t(3;21), t(l;3) or del(3)(q21). Three cases with t(3;21) (one Ph + ve) were de novo AML or had de novo aplastic anaemia. Survival was rarely greater than 12 months from detection of the 3qabn.