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Minor breakpoint cluster region (m‐BCR) positive chronic myeloid leukaemia with an acute lymphoblastic leukaemia onset: a case report
Author(s) -
Costello Régis T.,
Gabert Jean,
BRUNEL VÉRONIQUE,
Sainty Danielle,
Arnoulet Christine,
Mozziconacci MarieJoëlle,
Camerlo Jacques,
Perret Caroline,
Gastaut JeanAlbert,
Bouabdallah Reda,
LafagePochitaloff Mårina
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05317.x
Subject(s) - breakpoint cluster region , medicine , complete remission , philadelphia chromosome , chronic myeloid leukaemia , myeloid leukemia , spontaneous remission , myeloid , myeloid leukaemia , chemotherapy , immunology , pathology , chromosomal translocation , biology , receptor , biochemistry , alternative medicine , gene
Summary. m‐BCR chronic myeloid leukaemia (CML) is a rare entity. We report a patient presenting with Philadelphia (Ph)‐positive, m‐BCR‐positive acute lymphoblastic leukaemia (ALL) who achieved complete remission after induction chemotherapy, but showed a majority of Ph‐positive mitoses during this remission. A diagnosis of m‐BCR CML was established and the patient was given interferon a therapy. This is the first m‐BCR CML presenting as ab initio ALL. This report emphasizes the importance of karyotyping Ph‐positive ALL during remission so as not to misdiagnose CML patients who can benefit from Interferon therapy.