Premium
Splenic irradiation for chronic autoimmune thrombocytopenic purpura in patients with contra‐indications to splenectomy
Author(s) -
Caulier Marie Thearegse,
Darloy Franck,
Rose Christian,
Camier Ghislaine,
Morel Pierre,
Bauters Francis,
Fenaux Pierre
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05271.x
Subject(s) - splenectomy , medicine , thrombocytopenic purpura , spleen , surgery , gastroenterology , platelet
Summary We treated by splenic irradiation eight patients with chronic idiopathic thrombocytopenic purpura (ITP, seven cases) or secondary autoimmune thrombocytopenic purpura (one case) who had contra‐indications to splenectomy. A total dose of 15 Gy was delivered to the spleen, with left kidney protection. One patient had a good durable response (>1 year); two patients had a good transient response (of 3 months duration) but they responded again to a second course of irradiation; two patients had only partial response, but have required no other treatments for 2 years; the three remaining patients had no response. Side‐effects were minor. Therefore splenic irradiation appears to be a therapeutic option in patients with chronic ITP who have contra‐indications to splenectomy.