Bc16/Laz3 rearrangements in post‐transplant lymphoproliferative disorders | Zendy

Delecluse H. J. | Zendy; Rouault J. P. | Zendy; Jeammot B. | Zendy; Kremmer E. | Zendy; Bastard C. | Zendy; Berger F. | Zendy

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Bc16/Laz3 rearrangements in post‐transplant lymphoproliferative disorders

Author(s) -

Delecluse H. J.,

Rouault J. P.,

Jeammot B.,

Kremmer E.,

Bastard C.,

Berger F.

Publication year - 1995

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/j.1365-2141.1995.tb05252.x

Subject(s) - bcl6 , southern blot , lymphoproliferative disorders , epstein–barr virus , germline , biology , gene rearrangement , virus , virology , lymphoma , population , immunology , immune system , cancer research , gene , b cell , genetics , medicine , antibody , germinal center , environmental health

Summary Post‐transplant lymphoproliferative disorders (PTLD) are well‐known complications of iatrogenic immune deficiency and are thought to result from the proliferation of B cells infected by the Epstein‐Barr virus (EBV). Some large cell lymphomas occurring in the general population carry a rearrangement of the Bcl6/Laz3 zinc‐finger‐encoding gene. 15 EBV‐associated PTLD were tested for the presence of Bcl6/Laz3 rearrangements by Southern blot analysis using two specific probes (F3 70, F3 72), One out of 15 cases displayed a rearranged band independent of the germline one. In contrast, 10 lymphoblastoid cell lines and one lymphoblastoid cell line passaged in an SCID mouse carried only germline alleles of Bcl6/Laz3 after Southern blot hybridization. This indicates that genetic abnormalities may also play an important role in the development of some PTLD.

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