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GM‐CSF‐induced acute eosinophilic pneumonia
Author(s) -
SEEBACH JORG,
SPEICH RUDOLF,
FEHR JORG,
TUCHSCHMID PETER,
RUSSI ERICH
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05227.x
Subject(s) - medicine , eosinophilia , bronchoalveolar lavage , eosinophilic pneumonia , neutropenia , eosinophil , lobar pneumonia , lymphocytosis , immunology , pneumonia , pleural effusion , pathology , granulocytosis , gastroenterology , toxicity , granulocyte , lung , asthma
Summary. There is increasing evidence that haemopoietic growth factors are effective in reversal of neutropenia associated with large granular lymphocytes (LGLs) proliferation. A 19‐year‐old woman with CD3 + /TCRγδ + , CD4 − , CD8 − LGL proliferation and severe neutropenia repeatedly developed blood eosinophilia, fever and dyspnoea after administration of GM‐CSF. Acute eosinophilic pneumonia with a lobar lung infiltrate pleural effusion, and marked bronchoalveolar lavage fluid eosinophilia was diagnosed. Treatment with corticosteroids and discontinuation of GM‐CSF lead to rapid improvement. In addition, haematological analysis revealed that H*1 Technicon, a widely‐used automated cell counter, may misinterpret eosinophils erroneously as neutrophils, therefore examination of blood smears to prevent eosinophil‐medlated toxicity during GM‐CSF treatment is recommended.