Premium
Mobilization of CD34‐positive tumour cells in a patient with testicular mixed germ cell tumour
Author(s) -
VERBEEK WALTER,
PIES ANDREAS,
HUMPE ANDREAS,
GROVE DORIS,
TROFF CARMEN,
KUNZE EKKEHARD,
HIDDEMANN WOLFGANG,
WORMANN BERNHARD
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05222.x
Subject(s) - germ cell , cd34 , mobilization , medicine , testicle , germ , pathology , cancer research , oncology , biology , stem cell , microbiology and biotechnology , genetics , history , archaeology , gene
Summary. Tumour cells from a patient with recurrent testicular germ cell cancer and bone marrow infiltration were found to express CD33 and CD34 in the absence of other haemopoiesis‐associated antigens. After myelosup‐pression and treatment with G‐CSF for stem cell mobilization, CD34‐positive tumour cells were detected in the peripheral blood in addition to normal haemopoietic progenitor cells. The tumour cells were decreased in the leukapheresis product. Retrospectively, the appearance of tumour cells in the peripheral blood after stem cell mobilization was the first indication of impending relapse.