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Modulation of all‐trans retinoid acid pharmacokinetics in acute promyelocytic leukaemia by prolonged interferon‐α therapy
Author(s) -
LAZZARINO MARIO,
CORSO ALESSANDRO,
REGAZZI MARIO B,
IACONA ISABELLA,
BERNASCONI CARLO
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05217.x
Subject(s) - retinoid , pharmacokinetics , tretinoin , catabolism , medicine , pharmacology , interferon , acute promyelocytic leukemia , retinoic acid , immunology , chemistry , biochemistry , metabolism , gene
Summary. Continuous treatment with all‐trans retinoid acid (ATRA) induces accelerated drag catabolism which is considered responsible for acquired resistance to ATRA. We studied the effect of interferon‐o:2a (IFN) on ATRA pharmacokinetics in two patients with acute promyelocytic leukaemia (APL) in complete remission maintained by alternating 15d of IFN and 15 d of ATRA. Day 15 ATRA levels obtained during IFN + ATRA treatment were significantly higher than those observed in patients maintained on ATRA alone. In one patient IFN was discontinued and day 15 ATRA levels decreased to those observed in patients scheduled for maintenance with ATRA alone. In our two patients IFN substantially reduced the induction of ATRA catabolism, indicating a potential role for IFN in modulating ATRA pharmacokinetics.