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Persistence of multilineage host haemopoiesis following allogeneic bone marrow transplantation
Author(s) -
PRICE CATHY M.,
COLMAN SUSAN M.,
KANFER EDWARD J.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05177.x
Subject(s) - haematopoiesis , immunology , bone marrow , myeloid , cytotoxic t cell , stem cell , transplantation , progenitor cell , cd34 , biology , medicine , cancer research , in vitro , genetics
Summary. The survival of host cells following high‐dose cytotoxic therapy and allogeneic marrow transplantation has been established previously, but the identity of these cells has not been elucidated in detail. Four patients who received sex‐mismatched marrow have been studied for up to 12 months post‐transplant using a simultaneous immuno‐phenotyping/fluorescence in situ hybridization technique. The results demonstrate residual host T cells (CD3 + ), B cells (CD22+) and myeloid cells (CDllc+ and CD13+), and additionally cells of progenitor cell phenotype (CD34 + ). The long‐term persistence of host haemopoiesis may have major relevance to the post‐transplant complications of marrow rejection, graft‐versus‐host disease, and malignant relapse.