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Karyotypic evolution in a granulocytic sarcoma developing in a myeloproliferative disorder with a novel (3;4) translocation
Author(s) -
MYINT H.,
CHACKO J.,
MOULD S.,
ROSS F.,
OSCIER D. G.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05176.x
Subject(s) - chromosomal translocation , pathology , trisomy , sarcoma , cytogenetics , karyotype , chemotherapy , eosinophilia , biology , bone marrow , radiation therapy , chromosome , medicine , genetics , gene
Summary. A 59‐year‐old man presented with a granulocytic sarcoma arising in the manubrium, and splenomegaly. The blood count showed 1‐2 × 10 9 /1 eosinophils and a marrow aspirate was hypercellular with eosinophilia. Cytogenetic analysis of the marrow revealed a novel t(3;4) (pl3;ql2) and analysis of cells aspirated from the granulocytic sarcoma showed the same abnormality and an additional trisomy 8. Intensive chemotherapy and local radiotherapy led to resolution of the chest mass but persistence of the chromosome translocation in the marrow.