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Macrophage colony‐stimulating factor‐producing malignant histiocytosis
Author(s) -
OZAKI SHUJI,
MATSUSHITA TAKAYA,
IDE MAKOTO,
OZAKI KEIJI,
SANO TOSHIAKI,
KOSAKA MASAAKI,
SAITO SHIRO
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05173.x
Subject(s) - neutrophilia , malignant histiocytosis , histiocyte , pathology , medicine , macrophage , histiocytosis , cd68 , macrophage colony stimulating factor , bone marrow , immunohistochemistry , granulocyte macrophage colony stimulating factor , lymph , lymph node , histiocytic sarcoma , immunology , cytokine , biology , disease , biochemistry , in vitro
Summary. We describe a patient with malignant histiocytosis who had a prominent neutrophilia uncommonly observed in this disease. Serum concentration of macrophage colony‐stimulating factor (M‐CSF) was markedly elevated, and correlated with clinical symptoms and neutrophil counts during clinical course. Moreover, M‐CSF was detected in the cytoplasm of malignant histiocytes of the lymph node and bone marrow by immunohistochemical staining. These results indicate that the neutrophilia observed in this patient was caused by M‐CSF produced by the malignant histiocytes.