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Severe hypophosphataemia during stem cell harvesting in chronic myeloid leukaemia
Author(s) -
CLARK RICHARD E.,
LEE EDWIN S.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05172.x
Subject(s) - medicine , stem cell , chronic myeloid leukaemia , granulocyte colony stimulating factor , sepsis , myeloid , immunology , chemotherapy , white blood cell , oncology , biology , genetics
Summary. Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony‐stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, and fatal, hypophosphataemia and this coincided with the rapid rise of his peripheral blood white cell count. The hypophosphataemia was considered to be due to a combination of severe anorexia, sepsis and the rapid growth factor‐stimulated myeloid regeneration in CML.