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The effect of endogenous oestradiol levels on protein S concentration during a menstrual cycle and after GnRH analogues and gonadotropin therapy
Author(s) -
FALKON L.,
GARI M.,
MORA J. L. GARCIA,
CALAF J.,
ESPINOSA J. RODRIGUEZ,
OLIVER A.,
FONTCUBERTA J.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05171.x
Subject(s) - endogeny , endocrinology , medicine , gonadotropin , menstrual cycle , in vitro fertilisation , stimulation , gonadotropin releasing hormone , biology , chemistry , hormone , luteinizing hormone , embryo , microbiology and biotechnology
Summary. We studied two groups of females to investigate the effect of endogenous oestradiol levels on total and free protein S (tPS, fPS) plasma concentrations. One group (group I) consisted of 12 healthy volunteers who were studied throughout one menstrual cycle; the other group (group II) consisted of 16 young women who were treated with GnRH analogues and gonadotropins before undergoing in vitro fertilization. Neither tPS nor fPS varied significantly with respect to the physiological changes of oestradiol or to the very low and high levels of oestradiol, achieved after GnRH analogues suppression and gonadotropin stimulation. These results indicate that endogenous oestradiol does not affect PS concentration.