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Abnormal TCR V/3 repertoire in patients with chronic myeloid leukaemia
Author(s) -
COLEMAN S.,
PERERA P.,
FISHER J.,
HOY T.,
BURNETT A. K.,
LIM S. H.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05159.x
Subject(s) - chronic myeloid leukaemia , repertoire , medicine , myeloid leukaemia , t cell receptor , immunology , myeloid , t cell , immune system , physics , acoustics
Summary. We have used 25 sets of oligonucleotide primers specific for the 24 known major human T‐cell receptor (TCR) V/? families in polymerase chain reactions to analyse the T‐cell repertoire of the peripheral blood in seven patients with chronic myeloid leukaemia (CML). In contrast to normal healthy individuals, all seven patients exhibited variable degrees of TCR V/3‐specific T‐cell deletion, ranging from two to eight of the 24 major families. T cells bearing V/3 17 and 8 were most commonly deleted. These results suggest a superantigen effect associated with CML. The patterns of deletion did not appear to correlate with either of the two bcr‐abl transcripts. The reason and aetiological agent responsible for the T‐cell deletion remain speculative. Further work is ongoing to characterize this phenomenon in animal models and patients with CML.