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Expression of an erythropoietin‐like gene in the trout
Author(s) -
SHIELS A.,
WICKRAMASINGHE S. N.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb03406.x
Subject(s) - erythropoietin , erythropoiesis , rainbow trout , biology , northern blot , trout , radioimmunoassay , medicine , gene , gene expression , endocrinology , kidney , fish <actinopterygii> , anemia , genetics , fishery
Cross‐species Northern blot hybridization and radioimmunoassay have provided evidence for the expression of an erythropoietin (EPO)‐like gene in the rainbow trout. The principal site of EPO‐like mRNA and antigen expression in the adult trout appears to be the kidney which also acts as the major erythropoietic organ. The data suggest that a locally produced EPO‐like factor may regulate renal erythropoiesis in bony fish and, furthermore, they identify a possible evolutionary origin for renal EPO production in mammals.