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Successful bone marrow transplantation for idiopathic hypereosinophilic syndrome
Author(s) -
FOKUSHIMA TAKUYA,
KURIYAMA KAZUTAKA,
ITO HAJIME,
MIYAZAKI YASUSHI,
ARIMURA KOSEI,
HATA TOMOKO,
SAITOH MAMIKO,
TOMONAGA MASAO
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb03404.x
Subject(s) - medicine , hypereosinophilic syndrome , methylprednisolone , bone marrow , graft versus host disease , transplantation , eosinophilia , gastroenterology
A 21‐year‐old man who had an increased number of eosinophils with morphological abnormalities, bone marrow fibrosis and multiple organ dysfunction failed to respond to methylprednisolone and hydroxyurea. He was diagnosed with hypereosinophilic syndrome (HES) probably due to myeloproliferative disorder, and underwent allogeneic bone marrow transplantation (allo‐BMT) from an HLA‐identical sibling. The engraftment was confirmed on day 21 after BMT, but the patient developed acute graft‐versus‐host disease (GVHD) with grade I veno‐occlusive disease, and transient increase of eosinophils of the donor type followed by chronic GVHD of the extensive type. These complications were eventually controlled with cyclosporin A. The patient survived free of disease for more than a year after BMT. Allo‐BMT seems to be a possible treatment of HES/MPD.