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Resistance to activated protein C activity of an anti‐/ 2 ‐glycoprotein I antibody in the presence of β‐glycoprotein I
Author(s) -
MATSUDA Juzo,
GOTOH MORITAKA,
GOHCHI KENGO,
KAWASUGI KAZUO,
TSUKAMOTO MIYO,
SAITOH NORIKO
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb03401.x
Subject(s) - lupus anticoagulant , glycoprotein , antibody , p glycoprotein , activated protein c resistance , immunology , medicine , protein c , thrombosis , microbiology and biotechnology , chemistry , venous thrombosis , biology , biochemistry , factor v leiden , multiple drug resistance , antibiotics
Some researchers claim that lupus anticoagulant‐positive plasma may cause a false‐positive reaction in the test for activated protein C (APC) resistance, a hereditary thrombophilic state characterized by abnormal factor V, which frequently causes venous thrombosis, We investigated whether anti‐/3 2 ‐glycoprotein I antibody (aGPI), which has recently come to be regarded as an anti‐cardiolipin antibody (aCL) itself, might have an effect on the APC resistance test.