Premium
Scintigraphic evaluation of the haemopoietic bone marrow using a 99m Tc‐anti‐granulocyte antibody: a validation study with 52 Fe
Author(s) -
JAMAR FRANCOIS,
FIELD CATHERINE,
LENERS NORBERT,
FERRANT AUGUSTIN
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb03376.x
Subject(s) - bone marrow , spleen , granulocyte , haematopoiesis , pathology , aplastic anemia , technetium , monoclonal antibody , medicine , technetium 99m , nuclear medicine , antibody , scintigraphy , immunology , biology , stem cell , genetics
To specify the validity of bone marrow scanning using a monoclonal anti‐granulocyte antibody labelled with 99m Tc (BW 250/183) for the functional assessment of haemopoiesis, we compared this method with 52 Fe scan in 16 patients with haematological disorders. The examinations were performed using a rectilinear whole‐body scanner and the distribution of the two tracers was assessed visually and quantitatively in anatomical bone marrow segments, the spleen and liver. Qualitative comparison showed concordance in the bone marrow distribution of the two tracers in 83% of the segments. Discrepancies were found in six patients with hypoplastic or aplastic marrow. The spleen was visualized in all cases with the 99m Tc‐Moab, including nine patients without splenic haemopoiesis (i.e. without spleen uptake of 52 Fe). The uptake of the two tracers, quantified in bone marrow segments and the spleen, correlated well (PO‐0001), but not in the liver (NS). The correlation between the uptake values for each patient was excellent, except in cases of aplastic bone marrow. In conclusion, bone marrow scanning using a 99m Tc labelled anti‐granulocyte monoclonal antibody enables functional evaluation of the distribution of haemopoiesis. Limitations include the evaluation of bone marrow aplasia and identification of splenic haemopoiesis, for which 52 Fe remains the tracer of choice.