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Lymphoid blast crisis at the onset of chronic myelogenous leukaemia: molecular evidence
Author(s) -
Roman Jose,
Andres Pilar,
Jimenez Maria A.,
Torres Antonio
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb08325.x
Subject(s) - blast crisis , breakpoint cluster region , chronic myelogenous leukemia , bone marrow , medicine , precursor cell , immunology , gene rearrangement , cancer research , leukemia , biology , genetics , receptor , in vitro , gene
Summary A patient with a typical haematological pattern of acute lymphoblastic leukaemia with BCR and IgH rearrangements was brought into complete remission by treatment. A few weeks later she developed the typical peripheral and bone marrow pattern of chronic myelogenous leukaemia (CML) with persistence of the BCR rearrangement and disappearance of the IgH rearrangement, suggesting that this case is an example of CML presenting in blast crisis without a detectable chronic phase.