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Burkitt type leukaemia associated with multiple myeloma
Author(s) -
Kawachi Yasunori,
Sakamoto Yukihiro,
Shidahara Toshiki,
Abe Takako,
Uchida Tatsumi,
Sasaki Kazunori,
Ikeda Kazuma
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb08323.x
Subject(s) - multiple myeloma , bence jones protein , karyotype , cd20 , antibody , medicine , cd19 , immunoglobulin light chain , immunology , biology , chromosome , gene , genetics
We describe a 77‐year‐old man with multiple myeloma (MM) who developed Burkitt type leukaemia (BTL) 16 months after the initial diagnosis of MM. MM was positive for CD10 with immunoglobulin (Ig) κ, κ, Bence Jones protein (BJP) and a normal karyotype. BTL was positive for CD10, CD19, CD20 and HLA‐DR with Ig μ and γ, γBJP and a clonal abnormal karyotype of 46, XY, ‐13, t(8;14)(q24;q32), 11q+,14q+, +mar. The patient died 9 d after diagnosis of BTL despite treatment with multiple agents. This is, to our knowledge, the first such case to be reported.