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A case of severe neonatal thrombocytopenia with schizencephaly associated with anti‐HPA‐1 b and anti‐HPA‐2a
Author(s) -
Kuijpers Robert W. A. M.,
Anker John N. van den,
Baerts Wim,
Borne Albert E. G. Kr. von dem
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb08315.x
Subject(s) - medicine , schizencephaly , platelet , neonatal alloimmune thrombocytopenia , von willebrand factor , gestation , coagulopathy , antibody , immunology , fibrinogen , fetus , pregnancy , biology , magnetic resonance imaging , genetics , radiology
Summary We report a family with a neonate who was severely damaged by intracranial haemorrhages. These probably occurred before the 20th week of gestation. The neonate had a moderate thrombocytopenia. In the maternal serum anti‐HPA‐1b and anti‐HPA‐2a alloantibodies were detected. Third‐generation assays were applied to identify the alloantibodies. No other cause for the bleeding was found. Probably the combination of anti‐HPA‐1b and anti‐HPA‐2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy.