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Peripheral T cell receptors αβ and γδ in patients with Hodgkin's lymphoma
Author(s) -
Akan Hamdi,
Beksaçl Meral,
Aydoǧgdu Ismet,
Koçl Haluk,
Ilhan Osman,
ÖZcan Muhit
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb08310.x
Subject(s) - t cell receptor , cd3 , antigen , immunology , lymphoma , t cell , receptor , monoclonal antibody , t lymphocyte , monoclonal , biology , lymphoproliferative disorders , medicine , cd8 , antibody , immune system
Summary Antigen recognition by T cells is determined by an antigen specific T cell receptor (TCR). Two heterodimeric TCR structures associated with CD3 have been defined: TCR αβ and TCR γδ. TCR αβ and its function are well described but the role of TCR γδ in normal and lymphoproliferative disorders is not well established. In newly diagnosed or relapsed/refractory Hodgkin's disease (HD), a disease associated with defective T cell functions and increased sIL‐2R, We determined levels of seven TCR αβ variable regions [βV5(a), βV5(b), βV6(a), βV12(a), αβV(a), αV2(a)] and TCR γδ by using monoclonal antibodies (MCA). TCR γδ levels did not show any difference, but several variable regions of the TCR αβ differed when groups are compared with each other and the control group.