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The plasma concentration of soluble Fc‐gamma RIII is related to production of neutrophils
Author(s) -
Huizinga T. W. J.,
Haas M. de,
Oers M. H. J. van,
Kleijer M.,
Viléa H.,
Wouw P. A. van der,
Moulijn A.,
Weezel H. van,
Roos D.,
Borne A. E. G. Kr.von dem
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb08298.x
Subject(s) - chemistry , allotype , neutrophile , receptor , cd16 , immunology , dextran , antigen , biochemistry , biology , in vitro , cd3 , cd8
Summary. FcγRIII (the CD16‐antigen), a low‐affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of FcγRIII has been identified in human plasma. This soluble form of FcγRIII (sFcγRIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFcγRIII of one allotype (NA1‐FcγRIII) in recipients homozygous for the other allotype (NA2‐FcγRIII) that the clearance of sFcγRIII is about 0.7 ml/min. Because the concentration of sFcγRIII was found to be constant in a small cohort of donors followed for about 1‐5 years, the half‐life of NA1‐sFcγRIII is about 1.8 d, assuming a one‐compartment model. The plasma concentration of sFcγRIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because FcγRIII is only expressed on mature neutrophils, this implies that the concentration of sFcγRIII depends on production of mature neutrophils.