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Acquired sideroblastic anaemia following progesterone therapy
Author(s) -
Brodsky Robert A.,
Hasegawa Setsuo,
Fibach Eitan,
Dunber Cynthia E.,
Young Neal S.,
Rodgers Griffin P.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb06753.x
Subject(s) - medicine , sideroblastic anemia , intensive care medicine , obstetrics , anemia
Summary We report a case of acquired sideroblastic anaemia precipitated by progesterone. On two separate occasions, over 15 years apart, the patient developed sideroblastic anaemia with iron overload shortly after the administration of progesterone. No other cause for sideroblastic anaemia was found, and treatment with folic acid, pyridoxine or androgens corrected the anaemia. In both instances removal of the progestational agent led to prompt disappearance of the anaemia as well as the ringed sideroblasts. Using a two‐phase liquid culture procedure in which human peripheral blood‐derived progenitor cells undergo erythroid proliferation and differentiation. we demonstrated enhanced sensitivity of the patient's erythroid progenitors to progesterone. We conclude that progesterone should be added to the list of medications known to be associated with acquired sideroblastic anaemia.