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Hypercalcaemia in B cell chronic lymphocytic leukaemia
Author(s) -
Fain Olivier,
M'Selmi Abdellatif El,
Dosquet Christine,
Meseure Didier,
Lejeune Francloise,
Garel JeanMichel,
Thomas Michel
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb06752.x
Subject(s) - chronic lymphocytic leukemia , hypercalcaemia , medicine , b cell , leukemia , cancer research , immunology , antibody , calcium
Summary Hypercalcaemia is common in some lymphoproliferative disorders such as myeloma or T‐cell leukaemialymphoma. but is rarely described in B cell chronic lymphocytic leukaemia (BCLL). We report the case of a patient with BCLL, hypercalcaemia and osteolytic bone lesions. Parathyroid hromone‐related protein (PTHrP) mRNA was identified by Northern blot analysis of liver. spleen and lymph node tumour samples. Serum levels of tumour necrosis factor alpha (TNFα) were increased.