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Ten‐year survival and prognostic factors in multiple myeloma
Author(s) -
Tsuchiya Jun,
Murakami Hirokazu,
Kanoh Tadashi,
Kosaka Masaaki,
Sezaki Tatsuo,
Mikuni Chikara,
Kawato Masafumi,
Takagi Toshiyuki,
Togawa Atsushi,
Isobe Takashi,
Suzuki Kenshi,
Imamura Yukio,
Takatsuki Kiyoshi
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb06745.x
Subject(s) - multiple myeloma , medicine , bone marrow , univariate analysis , multivariate analysis , logistic regression , univariate , oncology , hypercalcaemia , survival analysis , plasma cell , multivariate statistics , statistics , mathematics , calcium
Summary. Among 1119 Japanese patients with symptomatic multiple myeloma diagnosed between 1965 and 1981, 38 (3.4%) survived more than 10 years. Younger age, low tumour mass (absence of severe anaemia, hypercalcaemia, renal failure, and multiple bone lesions), low plasma cell percentage in bone marrow, mature and intermediate myeloma according to Greipp's criteria, and a positive response to subsequent treatment, were related to long‐term survival according to univariate analysis. Multivariate logistic regression analysis indicated younger age and low tumour mass as pretreatment characteristics to be related to long‐term survival. Prognostic factors proposed applicable to myeloma were also related to 10‐year survival.