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A distinct coagulopathy associated with Interleukin‐2 therapy
Author(s) -
Oleksowicz Leslie,
Strack Margery,
Dutcher Janice P.,
Sussman Ira,
Caliendo Geralyn,
Sparano Joseph,
Wiernik Peter H.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb05135.x
Subject(s) - coagulopathy , medicine , interleukin , intensive care medicine , immunology , cytokine
Summary We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin‐2 (IL‐2). A 43% prolongation of the PTT (P<0.001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL‐2 treatment in comparison to pretreatment values. These parameters normalized within 2–3 d following IL‐2 administration. The PT, factors V. VII, VIII, fibrinogen and D‐dimer levels were unchanged with IL‐2 treatment. This pattern of coagulopathy has not previously been reported.