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Epstein‐Barr virus in familial Hodgkin's disease
Author(s) -
SCHLAIPER DANIEL,
RIGALHUGUET FRANCOISE,
ROBERT ALAIN,
ATTAL MICHEL,
ABBAL MICHEL,
FONCK YVETTE,
LAURENT GUY,
PRIS JACQUES,
DELSOL GEORGES,
BROUSSET PIERRE
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb05089.x
Subject(s) - virus , disease , epstein–barr virus , virology , medicine , biology , pathology
Summary Hodgkin's disease (HD) has been found to be linked to Epstein‐Barr virus (EBV). Familial HD (FHD) may be related to a possible unknown agent. We have determined whether EBV small RNAs (EBERs) were found in Reed‐Sternberg cells from FHD. Five families were studied for histological subtype and EBER presence. There was a striking similarity in FHD subtypes of each family and 3/11 (27%) of the cases were EBER positive. In conclusion, EBV EBERs are only infrequently found in FHD and other factors including viruses different from EBV should be further investigated in FHD.