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Use of G‐CSF alone to mobilize peripheral blood stem cells for collection from children
Author(s) -
Kanold J.,
Rapatel Ch.,
Berger M.,
Chassagne J.,
Lutz P.,
Lumley L. de,
Plantaz D.,
Vannier J. P.,
Malpuech G.,
Demécocq F.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb05088.x
Subject(s) - etoposide , cyclophosphamide , medicine , blood cancer , peripheral blood stem cells , haematopoiesis , peripheral blood , stem cell , neuroblastoma , chemotherapy , mobilization , oncology , hematopoietic stem cell transplantation , transplantation , biology , cancer , history , archaeology , genetics , cell culture
Summary We report the data of 19 children with neuroblastoma (NB) or Ewing's sarcoma (EW) who had peripheral blood stem cells (PBSCs) harvested after mobilization by: (1) cyclophosphamide (CY) + etoposide + G‐CSF, (2) CY+GM‐CSF, or (3) G‐CSF alon. There were no consistent differences in the number of PBSCs collected following these three different mobilization regimens as assessed by CFU‐GM. 17 patients were reinfused with PBSCs after myeloablative therapy and had successful haemopoietic recovery. These results show that in children with solid tumours such as NB or EW a sufficient number of PBSCs can be collected after G‐CSF alone, and that PBSCs collected following stimulation by G‐CSF alone are as effective in reconstituting haemopoiesis as those collected after mobilizing chemotherapy + HGFs.