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Chronic granulocytic leukaemia presenting with an extramedullary T lymphoblastic crisis
Author(s) -
Jacob A.,
Rowlands D. C.,
Patton N.,
Holmes J. A.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb05050.x
Subject(s) - hepatosplenomegaly , bone marrow , lymphoblastic lymphoma , medicine , lymphoma , breakpoint cluster region , lymph node , lymphoproliferative disorders , pathology , blast crisis , gene rearrangement , immunology , biology , t cell , genetics , immune system , gene , receptor , disease
Summary. A 33‐year‐old man presented with hepatosplenomegaly and lymphadenopathy. bone marow findings were consistent with Philadelphia‐positive acceleratedphase chronic granulocytic leukaemia (CGL). Lymph node histology and immunhistochemistry were diagnostic of T lymphoblastic lymphoma. Molecular studies on lymph node DNA identified rearrangement within the major breakpoint cluster region (M‐ber), indicating a common clonal origin of CGL and the T lymphoblastic lymphoma. We report the second case where extramedullary T lymphoblastic crisis was the presenting feature of CGL.