Premium
β 2 glycoprotein‐I antigen is increased in primary hyperlipidaemia
Author(s) -
McNally T.,
Crook M.,
Mackie I. J.,
Isenberg D. A.,
Machin S. J.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb05047.x
Subject(s) - triglyceride , medicine , glycoprotein , endocrinology , antigen , cholesterol , plasma levels , hyperlipidemia , chemistry , immunology , biochemistry , diabetes mellitus
Summary. In order to determine whether elevated levels of β 2 glycoprotein‐I (β 2 GPI) are associated with increased plasma lipids, we measured plasma β 2 GPI antigen levels in 47 patients with primary hyperlipidaemia (20 severe hypercholesterolaemia, nine severe hypertriglyceridaemia, and 18 mixed hyperlipidaemia) and 34 normal healthy subjects. Mean β 2 GPI levels were significantly increased in each patient group (302.3, 272.9 and 299.1 mg/1. respectively) compared to controls (199.6 mg/1) (p<0.01). Significant correlations were demonstrated between β 2 GPI levels and triglyceride and total cholesterol levels in the control group (r = 0.387, r =0.559: P<0.5), but were not observed in all patient groups. These results indicate that β 2 GPI is increased in hyperlipidaemia and that its distribution between plasma lipid fractions is perturbed. Plasma lipid levels should therfore be considered when interpreting results of β 2 GPI antigen assays.