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Hepatitis C virus infection in patients with non‐Hodgkin's lymphoma
Author(s) -
Ferri Clodoveo,
Caracciolo Francesco,
Zignego Anna Linda,
Civita Luca La,
Monti Monica,
Longombardo Giovanni,
Lombardini Francesco,
Greco Francesco,
Capochiani Enrico,
Mazzoni Alessandro,
Mazzaro Cesare,
Pasero Giampiero
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb05036.x
Subject(s) - lymphoma , hepatitis c virus , medicine , virus , non hodgkin's lymphoma , lymphoproliferative disorders , antibody , virology , immunology , hepatitis c
Summary. Hepatitis C virus (HCV), which is both a hepatotropic and a lymphotropic virus, has been proposed as a possible causative agent of mixed cryoglobulinaemia. This ‘benign’ lymphoproliferative disorder can switch over to a malignant B‐cell non‐Hodgkin's lymphoma (NHL). Therefore HCV infection has been investigated in a series of 50 unselected Italian patients with B‐cell NHL. Antibodies against HCV were found in 30% of NHL and HCV viraemia in 32% of cases. HCV‐related markers were detected in 34% (17/50) of our NHL patients; this prevalence is particularly significant when compared with HCV seropositivity in Hodgkin's lymphoma (3%) and healthy controls (1.3%).