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Eosinophilic leukaemia with a t(2;5) (p23;q35) translocation
Author(s) -
Sato Hiroshi,
Danbara Mikio,
Tamura Masato,
Morita Makoto
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04931.x
Subject(s) - chromosomal translocation , eosinophilia , hypereosinophilic syndrome , medicine , eosinophilic , bone marrow , immunology , pathology , biology , genetics , gene
SUMMARY. Although the diagnosis of rare eosinophilic leukaemia is possible based on cytogenetic abnormalities, the chromosomal aberrations reported are diverse. We found a t(2;5) (p23;q35) translocation on bone marrow cells of a patient with chronic eosinophilia who suffered from multiple pustular folliculitis but lacked the clinical symptoms commonly observed in hypereosinophilic syndrome. No morphological abnormalities in an eosinophilic series were apparent and other haemopoietic cells were well preserved. A therapeutic trial with interferon‐α failed after a 2‐month period, and the patient is currently undergoing a combination therapy with interferon and intermittent administrations of hydroxyurea.