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Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone
Author(s) -
Kamp Harmen van,
Smit Jan W.,
Berg Eva,
Halie M. Ruud,
Vellenga Edo
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04929.x
Subject(s) - clone (java method) , myelodysplastic syndromes , medicine , bone marrow failure , paroxysmal nocturnal hemoglobinuria , somatic evolution in cancer , stem cell , immunology , bone marrow , biology , haematopoiesis , genetics , gene , cancer
SUMMARY. A patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myelodysplasia the neutrophils of the patient fully expressed GPI‐linked proteins. It is concluded that the myelodysplasia does not originate from transformed PNH stem cells, but represents the emergence of a separate clone arising from an injured marrow.