Premium
Pancytopenia in allogeneic marrow transplant recipients: role of cytomegalovirus
Author(s) -
Bilgrami S.,
Almeida G. D.,
Quinn J. J.,
Tuck D.,
Bergstrom S.,
Dainiak N.,
Poliquin C.,
Ascensao J. L.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04922.x
Subject(s) - pancytopenia , medicine , cytomegalovirus , ganciclovir , immunology , bone marrow , bone marrow aplasia , betaherpesvirinae , foscarnet , herpesviridae , gastroenterology , human cytomegalovirus , viral disease , virus
SUMMARY. We describe the clinical course of three cytomegalovirus‐antibody‐positive allogeneic marrow graft recipients who developed progressive pancytopenia during the third month post‐transplant. Bone marrow biopsy cores were hypocellular without evidence of disease recurrence. Haemopoietic progenitor assays demonstrated a decrease of all assayable progenitors. Cytomegalovirus was identified from the blood and urine of all three patients. However, none of the patients developed other manifestations of cytomegalovirus infection such as pneumonitis, hepatitis and enteritis. The therapeutic use of ganciclovir and intravenous immunoglobulins resulted in prompt resolution of both viraemia and viruria in all three patients, and of pancytopenia in two patients.