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Postnatal changes of CD45 expression in peripheral blood T and B cells
Author(s) -
Lai Raymond,
Visser Lydia,
Poppema Sibrand
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04906.x
Subject(s) - peripheral blood , peripheral , expression (computer science) , immunology , medicine , biology , andrology , computer science , programming language
SUMMARY. One known postnatal change of CD45 expression is the decline of the CD45RA high CD45RO low T subsets and the reciprocal increase of the CD45RA low CD45RO high T subsets in the peripheral blood. Using a panel of monoclonal antibodies reactive with either protein or carbohydrate epitopes on the variable regions of CD45, we were able to detect more postnatal changes of CD45 expression. These changes are largely caused by modulation of the CD45 glycosylation, including: (I) lesser sialylation of the CD45RA region on T cells, and (2) differential sialylation of the CD45RB region leading to the distinction of CD45RB high and CD45RB low T and B subsets. In addition, the existence of the CD45RA dim CD45RO dim labelled as transitional T cells is only found during the postnatal life. These changes may reflect the maturation of the immune system.