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SLE x expression of normal CD 34 positive bone marrow haemopoietic progenitor cells
Author(s) -
Karakantza Marina,
Gibson Frances M.,
Cavenagh James D.,
Ball Sarah E.,
Gordon Myrtle Y.,
GordonSmith Edward C.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04850.x
Subject(s) - progenitor cell , bone marrow , monoclonal antibody , antigen , haematopoiesis , microbiology and biotechnology , immunology , progenitor , antibody , biology , pathology , cancer research , medicine , stem cell
Summary. We investigated sialylated Lewis x (sLe x ) antigen expression on CD 34 positive (CD 34 + ) haemopoietic progenitors in the bone marrow of eight healthy volunteers using monoclonal antibodies. We found that in all the samples examined, CD 34 + bone marrow progenitors strongly expressed the sLe x antigen. This contradicts previous publications which reported sLe x expression on malignant blast cells but not on normal CD 34 + progenitor cells.