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An atypical myeloproliferative disorder with t(8;13) (p11;q12): a third case
Author(s) -
Macdonald D.,
Sheerin S. M.,
Cross N. C. P.,
Spencer A.,
Goldman J. M.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04848.x
Subject(s) - chromosomal translocation , bone marrow , pathogenesis , myeloproliferative disorders , pathology , population , medicine , immunology , biology , genetics , gene , environmental health
Summary. A 43‐year‐old male presented with a myeloproliferative disorder with prominent lymphadenopathy. Examination of the bone marrow showed almost complete replacement by a population of cells with an acquired chromosomal translocation t(8;13) (p11;q12). There are two other case reports describing a similar clinical syndrome with t(8;13) (p11;12) as the sole chromosomal aberration in bone marrow cells, suggesting a role for this translocation in the pathogenesis of this myeloproliferative disorder.