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Successful treatment of transfusion‐associated graft‐versus‐host disease
Author(s) -
Yasukawa Masaki,
Shinozaki Fumiki,
Hato Takaaki,
Takada Kiyonori,
Ishii Yuko,
Tamai Tomonori,
Takamatsu Hideyuki,
Shiobara Shintaro,
Yoshizaki Kenichi,
Fujita Shigeru
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04838.x
Subject(s) - medicine , graft versus host disease , monoclonal antibody , disease , blood transfusion , immunology , transfusion therapy , immunotherapy , monoclonal , antibody , immune system
Summary. We present an immunocompetent patient with transfusion‐associated graft‐versus‐host disease (GVHD), in which chimaerism of peripheral blood lymphocytes was demonstrated by analysis of a highly polymorphic genome. The patient was treated successfully with anti‐CD 3 monoclonal antibody, OKT3 and cyclosporin A. Although it is undoubtedly important to prevent transfusion‐associated GVHD by irradiation of cellular blood components, intensive therapy with OKT3 and cyclosporin A in the early phase of onset may be effective for treatment of this potentially fatal condition. The mechanism of the effectiveness of this treatment for transfusion‐associated GVHD is discussed.