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Trisomy 8q due to i(8q) or der(8) t(8;8) is a frequent lesion in T‐prolymphocytic leukaemia: four new cases and a review of the literature
Author(s) -
Mossafa Hossain,
Brizard André,
Huret JeanLoup,
Brizard Françoise,
Lessard Michel,
Guilhot François,
Tanzer Joseph
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04829.x
Subject(s) - isochromosome , prolymphocytic leukemia , trisomy , chromosomal translocation , karyotype , pathology , medicine , biology , chronic lymphocytic leukemia , leukemia , chromosome , genetics , gene
Summary. Cytogenetic abnormalities found in four cases of T‐cell prolymphocytic leukaemia (T‐PLL) are described. An isochromosome 8q was found in three patients and a t(8;8) in one. In the four cases, karyotypes were complex and showed a high degree of instability. In addition, we reviewed 27 published cases of cytogenetically studied T‐PLL. On the whole, the most frequently recurring anomalies in T‐PLL are 14q lesions with nonrandom breakpoints, inversion (14)(q11q32) or tandem translocations (14;14) (not seen in any of our cases) and trisomy for 8q, mainly due to i(8q), found in more than 40% of patients each. Similar structural anomalies were found almost as frequently among the 23 cytogenetically studied cases of so‐called T‐chronic lymphocytic leukaemia (T‐CLL) reported prior to 1989. It is now accepted that the T‐cell counterpart of B‐CLL either does not exist or is exceedingly rare and thus previously reported cases of T‐CLL sharing the chromosomal characteristics of T‐PLL may well have been misdiagnosed examples of T‐PLL. Isochromosomes 8q are exceptionally found in other types of haematological malignancies. However, i(8q) could not be shown to be the primary lesion in any case in T‐PLL and the role of trisomy for 8q, as well of the associated monosomy 8p, is entirely unknown.