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Elevation of serum M‐CSF concentrations during pregnancy and ovarian hyperstimulation
Author(s) -
Praloran Vincent,
Coupey Lionel,
Donnard Magali,
Berrada Lamya,
Naud Marie Françoise
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04809.x
Subject(s) - gestation , ovarian hyperstimulation syndrome , endocrinology , pregnancy , controlled ovarian hyperstimulation , haematopoiesis , medicine , in vitro fertilisation , biology , andrology , stem cell , genetics
Summary. Macrophage colony stimulating factor (CSF‐1 or M‐CSF) is involved in haemopoiesis and probably in mouse gestation. Sexual steroids induce its production by uterine glandular epithelial cells and its receptor (product of the protooncogene C‐FMS) is expressed on placental trophoblastic cells. We measured M‐CSF serum levels in 119 pregnant women and in eight women undergoing ovarian hyperstimulation for in vitro fertilization. M‐CSF increased early (4–8 weeks) and progressively during gestation. Its rapid elevation during the course of ovarian hyperstimulation suggests that its synthesis is probably induced by sexual steroids. This locally produced M‐CSF could play a role in human pregnancy and in the pathogenesis of thrombocytopenias observed during pregnancy.