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Raised urinary calmodulin levels in idiopathic myelofibrosis: possible implications for the aetiology of fibrosis
Author(s) -
Eastham J. M.,
Reilly J. T.,
Neil S.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04807.x
Subject(s) - calmodulin , myelofibrosis , platelet , pathogenesis , fibrosis , immunology , medicine , endocrinology , biology , calcium , bone marrow
Summary. Platelet growth factors (e.g. PDGF and TGF‐β) are thought to be pathogenetically important in the stromal reaction characteristic of idiopathic myelofibrosis (IM). We have investigated a possible pathogenetic role for a further platelet mitogen, calmodulin. Platelets are rich in calmodulin, of which 30–40% is releasable with a time course that differs from α‐granule proteins. In IM urinary calmodulin concentrations were 3‐fold those of the normals controls. We suggest that an abnormal release of calmodulin may occur from platelets/megakaryocytes in patients with IM, and that calmodulin should be considered, along with other growth factors, in the pathogenesis of marrow fibrosis.