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Marked and reproducible increase in trilineage blood cell counts by administration of granulocyte colony‐stimulating factor in a patient with refractory anaemia with excess blasts in transformation
Author(s) -
Chiba Shigeru,
Inamori Ken,
Mitani Kinuko,
Hirai Hisamaru,
Yazaki Yoshio
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb04806.x
Subject(s) - pancytopenia , granulocyte colony stimulating factor , refractory (planetary science) , granulocyte , bone marrow , medicine , platelet , immunology , colony stimulating factor , gastroenterology , chemotherapy , biology , haematopoiesis , stem cell , astrobiology , genetics
Summary. We report a patient with refractory anaemia with excess blasts in transformation (RAEB‐t) who presented with severe pancytopenia and received four intermittent series of granulocyte colony‐stimulating factor (G‐CSF) treatment over 1·5 years. In addition to the increase in mature neutrophils, platelet count and haemoglobin level were dramatically increased. These haematological improvements were dependent on G‐CSF during these treatment series. Bone marrow colony assay revealed that G‐CSF increased both CFU‐E‐ and BFU‐E‐derived colonies in vitro. Clinical usage of G‐CSF in myelodysplastic syndrome (MDS) is discussed, with particular emphasis on mechanisms of trilineage response.